GeneID: 379
Names
| Common Name: | ATF4 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 22 (NC_000022.11) | Locus: | NM_001675.4 (ATF4) |
| HUGO Symbol: | ATF4 | Full Name: | activating transcription factor 4 |
| Exons: | 2 | Introns: | 1 |
Description:
The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These proteins bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. CRISPR-Cas screening in HUDEP-2 cells identified ATF4 as a regulator of γ-globin transcription through direct transcriptional control of BCL11A, a known repressor of γ-globin transcription. ATF4 stimulates transcription of BCL11A by binding to its enhancer (+55) and increasing enhancer-promoter contacts. ATF4 is regulated by HRI [GeneID: 264], and serves as a critical component in γ-globin silencing (linear signaling pathway from HRI to ATF4 to BCL11A to γ-globin).
Synonyms: CREB2 , TXREB , CREB-2 , TAXREB67
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA, The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression., Blood, 135(24), 2121-2132, 2020