GeneID: 377


Common Name: CYB5R3 Type: Gene
Chromosome: 22 (NC_000022.11) Locus: NG_012194.1 (CYB5R3)
HUGO Symbol: CYB5R3 Full Name: cytochrome b5 reductase 3
Exons: 9 Introns: 8

Nicotinamide adenine dinucleotide (NADH) cytochrome b5 (Cyb5) reductase 3 (CYB5R3) is a flavoprotein that transfers electrons from NADH through Cyb5 to an electron acceptor. It exists in membrane-bound and soluble forms. The membrane-bound enzyme participates in physiologic processes, including fatty acid desaturation and drug metabolism, whereas the soluble enzyme is present in erythrocytes and functions in methaemoglobin reduction. CYB5R3 plays a role in NO-sGC-cGMP signaling and has been implicated in the development of vascular and organ pathology in sickle cell disease.

Synonyms: B5R , DIA1


Sequence Viewer

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Publications / Origin

  1. Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC, Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling., Circ. Res., 121(2), 137-148, 2017 PubMed
  2. Wood KC, Durgin BG, Schmidt HM, Hahn SA, Baust JJ, Bachman T, Vitturi DA, Ghosh S, Ofori-Acquah SF, Mora AL, Gladwin MT, Straub AC, Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice., Blood Adv, 3(23), 4104-4116, 2019 PubMed
Created on 2020-05-07 15:39:08, Last reviewed on (Show full history)

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