GeneID: 372


Names

Common Name: IKAROS Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_034231.1 (IKZF1)
HUGO Symbol: IKZF1 Full Name: IKAROS family zinc finger 1
Exons: 8 Introns: 7

Description:
The IKZF1 gene encodes a member of a family of haematopoietic zinc finger transcription factors. It is a transcription regulator of haematopoietic cell differentiation. It has been associated with histone-modifying and chromatin-remodeling activities and shown to target the PYR complex (SWI/SNF and NuRD components) to a region between the γ- and β-globin genes, promoting globin gene switching. It interacts with GATA-1, a major erythroid transcription factor, and enhances its binding to different regulatory regions across the β-globin gene locus. Ikaros has been associated with γ-globin gene silencing.

Synonyms: K1 , LYF1 , LyF-1 , CVID13 , IKAROS , PPP1R92 , PRO0758 , ZNFN1A1 , Hs.54452

Comments:
N/A

Publications / Origin

  1. Dijon M, Bardin F, Murati A, Batoz M, Chabannon C, Tonnelle C, The role of Ikaros in human erythroid differentiation., Blood, 111(3), 1138-46, 2008
  2. Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E, Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes., Mol. Cell. Biol., 29(6), 1526-37, 2009
Created on 2020-03-27 19:13:39, Last reviewed on 2020-03-27 19:14:34 (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.