GeneID: 372
Names
| Common Name: | IKAROS | Type: | Gene |
|---|---|---|---|
| Chromosome: | 7 (NC_000007.14) | Locus: | NG_034231.1 (IKZF1) |
| HUGO Symbol: | IKZF1 | Full Name: | IKAROS family zinc finger 1 |
| Exons: | 8 | Introns: | 7 |
Description:
The IKZF1 gene encodes a member of a family of haematopoietic zinc finger transcription factors. It is a transcription regulator of haematopoietic cell differentiation. It has been associated with histone-modifying and chromatin-remodeling activities and shown to target the PYR complex (SWI/SNF and NuRD components) to a region between the γ- and β-globin genes, promoting globin gene switching. It interacts with GATA-1, a major erythroid transcription factor, and enhances its binding to different regulatory regions across the β-globin gene locus. Ikaros has been associated with γ-globin gene silencing.
Synonyms: K1 , LYF1 , LyF-1 , CVID13 , IKAROS , PPP1R92 , PRO0758 , ZNFN1A1 , Hs.54452
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Dijon M, Bardin F, Murati A, Batoz M, Chabannon C, Tonnelle C, The role of Ikaros in human erythroid differentiation., Blood, 111(3), 1138-46, 2008
- Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E, Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes., Mol. Cell. Biol., 29(6), 1526-37, 2009