GeneID: 370


Names

Common Name: Mi-2a Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NM_001005273.3 (CHD3)
HUGO Symbol: CHD3 Full Name: chromodomain helicase DNA binding protein 3
Exons: 40 Introns: 39

Description:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD3 is a key component of NuRD, a protein complex that comprises both nucleosome remodeling and deacetylase activities. The NuRD complex has been associated with epigenetic mechanisms of transcriptional repression during development, and has been shown to play an important role in globin regulation.

Synonyms: ZFH , SNIBCPS , Mi2-ALPHA

Comments:
N/A

Number of entries/variants: 0

IthaScore

Publications / Origin

  1. Bauer DE, Kamran SC, Orkin SH, Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders., Blood, 120(15), 2945-53, 2012
  2. Thein SL, Genetic association studies in β-hemoglobinopathies., Hematology Am Soc Hematol Educ Program, 2013(0), 354-61, 2013
  3. Hoffmeister H, Fuchs A, Erdel F, Pinz S, Gröbner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Längst G, CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality., Nucleic Acids Res., 45(18), 10534-10554, 2017
Created on 2020-03-27 17:38:19, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.