GeneID: 368


Common Name: NFE4 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NM_001085386.2 (NFE4)
HUGO Symbol: NFE4 Full Name: nuclear factor, erythroid 4
Exons: 2 Introns: 1

The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the γ-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress γ-globin gene expression. Enforced expression of p22 NF-E4 in cultured human erythroid cells and in β-YAC transgenic mice increased fetal globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand.

Synonyms: NF-E4


Sequence Viewer

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Publications / Origin

  1. Zhou W, Clouston DR, Wang X, Cerruti L, Cunningham JM, Jane SM, Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4., Mol. Cell. Biol., 20(20), 7662-72, 2000 PubMed
  2. Zhou W, Zhao Q, Sutton R, Cumming H, Wang X, Cerruti L, Hall M, Wu R, Cunningham JM, Jane SM, The role of p22 NF-E4 in human globin gene switching., J. Biol. Chem., 279(25), 26227-32, 2004 PubMed
Created on 2020-03-27 15:17:06, Last reviewed on (Show full history)

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