GeneID: 367


Common Name: PRMT1 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NG_031846.1 (PRMT1)
HUGO Symbol: PRMT1 Full Name: protein arginine methyltransferase 1
Exons: 11 Introns: 10

PRMT1 belongs to the protein arginine methyltransferase (PRMT) enzyme family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. It is involved in a variety of processes, including gene transcription, DNA repair, and signal transduction. It has been associated with human γ-globin gene silencing through association with a protein named friend of PRMT1, aka FOP [GeneID: 349]. PRMT1-mediated dimethyl H4R3 at HS2 of the βLCR has been shown to facilitate histone H3 acetylation on Lys9/Lys14 (AcH3K9/K14) and subsequent transcription of the adult β-globin gene.

Synonyms: ANM1 , HCP1 , IR1B4 , HRMT1L2


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Publications / Origin

  1. van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S, Fetal globin expression is regulated by Friend of Prmt1., Blood, 116(20), 4349-52, 2010 PubMed
  2. Li X, Hu X, Patel B, Zhou Z, Liang S, Ybarra R, Qiu Y, Felsenfeld G, Bungert J, Huang S, H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation., Blood, 115(10), 2028-37, 2010 PubMed
Created on 2020-03-27 12:32:21, Last reviewed on (Show full history)

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