GeneID: 366


Common Name: PRMT5 Type: Gene
Chromosome: 14 (NC_000014.9) Locus: NM_006109.5 (PRMT5)
HUGO Symbol: PRMT5 Full Name: protein arginine methyltransferase 5
Exons: 17 Introns: 16

PRMT5 belongs to the methyltransferase enzyme family. It catalyzes the transfer of methyl groups to the amino acid arginine in target proteins, which include histones, transcriptional elongation factors and small nuclear ribonucleoproteins (snRNP). It plays a role in several cellular processes, including transcriptional regulation and assembly of spliceosomal snRNP core particles. PRMT5 interacts with a nuclear zinc finger protein, LYAR , which directly binds to the 5′UTR of the γ-globin gene. PRMT5 mediates the methylation of histone H4 arginine 3 (H4R3me2s), which is implicated to signal the recruitment of additional chromatin modifying enzymes to the γ-globin promoter, repressing γ-globin gene expression.

Synonyms: HSL7 , JBP1 , SKB1 , IBP72 , SKB1Hs , HRMT1L5


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Publications / Origin

  1. Rank G, Cerruti L, Simpson RJ, Moritz RL, Jane SM, Zhao Q, Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression., Blood, 116(9), 1585-92, 2010 PubMed
  2. Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q, Human fetal globin gene expression is regulated by LYAR., Nucleic Acids Res., 42(15), 9740-52, 2014 PubMed
Created on 2020-03-27 11:50:25, Last reviewed on 2020-03-27 18:09:50 (Show full history)

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