GeneID: 362


Common Name: HLA-DPB1 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_033242.1 (HLA-DPB1)
HUGO Symbol: HLA-DPB1 Full Name: major histocompatibility complex, class II, DP beta 1
Exons: 6 Introns: 5

HLA-DPB belongs to the HLA class II beta chain paralogues. The DP subregion of the HLA class II D region contains genes encoding the alpha and beta chains of a heterodimeric, cell-surface glycoprotein that presents antigens to CD4 T-cells. Because the HLA class II molecules are highly polymorphic, they can embrace a wide variety of antigens in their antigen-binding groove and present them to diverse T-lymphocyte antigen receptors, triggering antigen recognition. The HLA genes regulate inflammation. Specific HLA-DPB1 alleles (e.g., DPB1*1701 and DPB1*0401) have been associated with risk for stroke in patients with sickle cell anaemia.

Synonyms: DPB1 , HLA-DP , HLA-DPB , HLA-DP1B


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Publications / Origin

  1. Hoppe C, Klitz W, Noble J, Vigil L, Vichinsky E, Styles L, Distinct HLA associations by stroke subtype in children with sickle cell anemia., Blood, 101(7), 2865-9, 2003 PubMed
  2. Hoppe C, Klitz W, Cheng S, Apple R, Steiner L, Robles L, Girard T, Vichinsky E, Styles L, , Gene interactions and stroke risk in children with sickle cell anemia., Blood , 103(6), 2391-6, 2004 PubMed
Created on 2020-03-26 10:42:36, Last reviewed on 2020-03-26 10:44:51 (Show full history)

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