GeneID: 362
Names
| Common Name: | HLA-DPB1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 6 (NC_000006.12) | Locus: | NG_033242.1 (HLA-DPB1) |
| HUGO Symbol: | HLA-DPB1 | Full Name: | major histocompatibility complex, class II, DP beta 1 |
| Exons: | 6 | Introns: | 5 |
Description:
HLA-DPB belongs to the HLA class II beta chain paralogues. The DP subregion of the HLA class II D region contains genes encoding the alpha and beta chains of a heterodimeric, cell-surface glycoprotein that presents antigens to CD4 T-cells. Because the HLA class II molecules are highly polymorphic, they can embrace a wide variety of antigens in their antigen-binding groove and present them to diverse T-lymphocyte antigen receptors, triggering antigen recognition. The HLA genes regulate inflammation. Specific HLA-DPB1 alleles (e.g., DPB1*1701 and DPB1*0401) have been associated with risk for stroke in patients with sickle cell anaemia.
Synonyms: DPB1 , HLA-DP , HLA-DPB , HLA-DP1B
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Hoppe C, Klitz W, Noble J, Vigil L, Vichinsky E, Styles L, Distinct HLA associations by stroke subtype in children with sickle cell anemia., Blood, 101(7), 2865-9, 2003 PubMed
- Hoppe C, Klitz W, Cheng S, Apple R, Steiner L, Robles L, Girard T, Vichinsky E, Styles L, , Gene interactions and stroke risk in children with sickle cell anemia., Blood , 103(6), 2391-6, 2004 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2020-03-26 10:42:36 | The IthaGenes Curation Team | Created |
| 2 | 2020-03-26 10:44:51 | The IthaGenes Curation Team | Reviewed. Links added. |