GeneID: 360


Common Name: HLA-DQB1 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_029922.1 (HLA-DQB1)
HUGO Symbol: HLA-DQB1 Full Name: major histocompatibility complex, class II, DQ beta 1
Exons: 6 Introns: 5

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The HLA-DQB1 gene has several alleles, which associated with response to severe infections in sickle cell disease (DQB1*03 and DQB1*06) and alloimmunisation in polytransfused patients with sickle cell anaemia (DQB1*03).

Synonyms: IDDM1 , CELIAC1 , HLA-DQB


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Tamouza R, Neonato MG, Busson M, Marzais F, Girot R, Labie D, Elion J, Charron D, Infectious complications in sickle cell disease are influenced by HLA class II alleles., Hum. Immunol., 63(3), 194-9, 2002 PubMed
  2. Rodrigues C, Sell AM, Guelsin GAS, Higa TT, Pagliarini E Silva S, Macedo LC, Sippert EÂ, de Alencar JB, Zanette Â, Acorsi CRL, Castilho L, Visentainer JEL, HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia., Transfus Med, 27(6), 437-443, 2017 PubMed
Created on 2020-03-25 12:49:55, Last reviewed on 2020-08-05 14:05:05 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.