GeneID: 359


Common Name: HLA-DRB1 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_029921.1 (HLA-DRB1)
HUGO Symbol: HLA-DRB1 Full Name: major histocompatibility complex, class II, DR beta 1
Exons: 6 Introns: 5

HLA-DRB1 encodes the beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. The HLA-DRB1 gene has several alleles, which associated with response to severe infections in sickle cell disease (DRB1*15) and with alloantibody production (anti-K and/or anti-E and/or anti-Fy) in transfusion-dependent thalassaemia (DRB1*15, DRB1*11) and polytransfused patients with sickle cell anaemia (DRB1*11, DRB1*04).

Synonyms: SS1 , DRB1 , HLA-DRB , HLA-DR1B


Sequence Viewer

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Publications / Origin

  1. Tamouza R, Neonato MG, Busson M, Marzais F, Girot R, Labie D, Elion J, Charron D, Infectious complications in sickle cell disease are influenced by HLA class II alleles., Hum. Immunol., 63(3), 194-9, 2002 PubMed
  2. Rodrigues C, Sell AM, Guelsin GAS, Higa TT, Pagliarini E Silva S, Macedo LC, Sippert EÂ, de Alencar JB, Zanette Â, Acorsi CRL, Castilho L, Visentainer JEL, HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia., Transfus Med, 27(6), 437-443, 2017 PubMed
  3. Ebrahimi M, Maleknia M, Parav N, Mohammadi MB, Mortazavi Y, Saki N, Rahim F, The HLA-DRB1*11 group-specific allele is a predictor for alloantibody production in the transfusion-dependent thalassemia patients., Transfus. Apher. Sci., 59(3), 102729, 2020 PubMed
  4. Ebrahimi M, Dayer D, Jalalifar MA, Keikhaei B, Tahan Nejad Asadi Z, Association between HLA-DRB1*01 and HLA-DRB1*15 with alloimmunisation in transfusion-dependent patients with thalassaemia., Transfus Med, 2020 PubMed
Created on 2020-03-25 12:46:45, Last reviewed on 2020-08-05 14:00:59 (Show full history)

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