GeneID: 351

Names

Common Name:	EHMT1	Type:	Gene
Chromosome:	9 (NC_000009.12)	Locus:	NG_011776.1 (EHMT1)
HUGO Symbol:	EHMT1	Full Name:	euchromatic histone lysine methyltransferase 1
Exons:	27	Introns:	26

Description:
The protein encoded by this gene is a histone methyltransferase that specifically mono- and di-methylates the lysine-9 position of histone H3 (H3K9me1 and H3K9me2, respectively). Together with EHMT2, forms a heterodimeric complex (EHMT1/2) that catalyzes the methylation of H3K9. This methylation is associated with gene silencing in euchromatin. EHMT1/2 complex inhibition activates fetal globin gene expression and leads to an increase in the activating mark H3K9Ac at the γ-globin gene locus in adult human erythroid cells.

Synonyms: GLP , GLP1 , KMT1D , KLEFS1 , FP13812 , EHMT1-IT1 , EUHMTASE1 , Eu-HMTase1

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL, EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression., Blood, 126(16), 1930-9, 2015 PubMed

Created on 2020-01-10 14:13:17, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2020-01-10 14:13:17	The IthaGenes Curation Team	Created

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