GeneID: 350

Description:
This gene encodes a member of the steroid/thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand-activated transcription factor (TF) that is involved in the regulation of many different genes. NR2F2, commonly referred to as COUP-TFII (chicken ovalbumin upstream promoter TF II), plays a central role in the transcriptional regulation of γ-globin genes. It acts as a negative regulator of fetal haemoglobin (HbF) levels. In the γ-promoter, COUP-TFII binds to the distal CCAAT region, preventing NF-Y binding to this overlapping region. COUP-TFII repression may contribute to the hereditary persistence of HbF phenotype. COUP-TFII interacts with the Erk1/2 MAPK pathway, which is involved in erythroid differentiation. COUP-TFII binds BCL11A at two motifs (RID1 and RID2), forming a repressor complex that is able to bind to key regulation regions in γ-globin genes.

Synonyms: ARP1 , ARP-1 , CHTD4 , NF-E3 , SVP40 , COUPTF2 , COUPTFB , TFCOUP2

Comments:
N/A

Number of entries/variants: 0

1. Liberati C, Cera MR, Secco P, Santoro C, Mantovani R, Ottolenghi S, Ronchi A, Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters., J. Biol. Chem., 276(45), 41700-9, 2001 PubMed
2. Moré E, Fellner T, Doppelmayr H, Hauser-Kronberger C, Dandachi N, Obrist P, Sandhofer F, Paulweber B, Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines., J. Endocrinol., 176(1), 83-94, 2003 PubMed
3. Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP, SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII., Blood, 114(1), 187-94, 2009 PubMed
4. Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM, A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors., Nucleic Acids Res., 41(21), 9663-79, 2013 PubMed