GeneID: 342
Names
| Common Name: | HSF1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 8 (NC_000008.11) | Locus: | NM_005526.4 (HSF1) |
| HUGO Symbol: | HSF1 | Full Name: | heat shock transcription factor 1 |
| Exons: | 13 | Introns: | 12 |
Description:
The product of the HSF1 gene functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, also called heat shock proteins (HSPs), which assist in refolding or degrading injured intracellular proteins. HSF1 is recognized as a putative regulator of fetal γ-globin gene expression during eryrthroid differentiation. Mechanistically, HSF1 binds to the LCR HS3 region via its canonical binding motif (TTCnnGAAnnTTC), indicating that this gene is involved in LCR-mediated long-range regulation of γ-globin and β-globin genes during erythropoiesis.
Synonyms: HSTF1
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Barna J, Csermely P, Vellai T, Roles of heat shock factor 1 beyond the heat shock response., Cell. Mol. Life Sci., 75(16), 2897-2916, 2018
- Gao J, Liu J, Zhang L, Zhang Y, Guo Q, Li Y, Tong J, Wang H, Zhou J, Zhu F, Shi L, Zhao H, Heat shock transcription factor 1 regulates the fetal γ- and adult β-globin expression in a stress-dependent and independent manner during erythroid differentiation., Exp. Cell Res., 2019