GeneID: 339


Common Name: LY6G5C Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NM_025262.3 (LY6G5C)
HUGO Symbol: LY6G5C Full Name: lymphocyte antigen 6 family member G5C
Exons: 3 Introns: 2

LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction. LY6G5C gene was differentially expressed in megakaryocytes, indicating that the encoded membrane protein could possibly have a modulatory role in platelet function. Genetic variance in LY6G5C gene associated with haematological parameters (e.g., platelet count).

Synonyms: G5c , NG33


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Publications / Origin

  1. Mallya M, Campbell RD, Aguado B, Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms., Genomics, 80(1), 113-23, 2002 PubMed
  2. Macaulay IC, Tijssen MR, Thijssen-Timmer DC, Gusnanto A, Steward M, Burns P, Langford CF, Ellis PD, Dudbridge F, Zwaginga JJ, Watkins NA, van der Schoot CE, Ouwehand WH, Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins., Blood, 109(8), 3260-9, 2007 PubMed
  3. Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015 PubMed
Created on 2019-12-10 12:24:23, Last reviewed on (Show full history)

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