GeneID: 333
Names
| Common Name: | RPL18P9-CCND2-AS1 | Type: | Intergenic Region |
|---|---|---|---|
| Chromosome: | 12 (NC_000012.12) | Locus: | N/A |
| HUGO Symbol: | RPL18P9-CCND2-AS1 | Full Name: | N/A |
| Exons: | N/A | Introns: | N/A |
Description:
RPL18P9 (ribosomal protein L18 pseudogene 9) is one of the many processed pseudogenes of ribosomal proteins. Processed pseudogenes are formed by reverse transcription and integration of processed mRNA into the genome by L1 transposons. Cyclin D2 (CCND2) belongs to the group of D-type cyclins with a critical function in cell cycle progression and tumorigenicity. CCND2 antisense RNA 1 (CCND2-AS1) is a long non-coding RNA (lncRNA) first found in glioma malignancy. It promotes glioma cell proliferation through Wnt/β-catenin signaling. Genetic variance in the RPL18P9-CCND2-AS1 intergenic region associated with haematological parameters (e.g., red blood cell count).
Synonyms: N/A
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Balasubramanian S, Zheng D, Liu YJ, Fang G, Frankish A, Carriero N, Robilotto R, Cayting P, Gerstein M, Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes., Genome Biol., 10(1), R2, 2009
- Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015
- Zhang H, Wei DL, Wan L, Yan SF, Sun YH, Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling., Biochem. Biophys. Res. Commun., 482(4), 1219-1225, 2017