GeneID: 332



Names

Common Name: CDK6 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_015888.1 (CDK6)
HUGO Symbol: CDK6 Full Name: cyclin dependent kinase 6
Exons: 8 Introns: 7

Description:
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. CDK6 is a key player in the differentiation of a variety of cell types, including osteoclasts, astrocytes, thymocytes and myeloid cells. CDK6 kinase activity is required for erythroid cytoskeletal organization/dynamics with effects on erythrocyte lifespan. Genetic variance in CDK6 gene associated with haematological parameters (e.g., white blood cell count).

Synonyms: MCPH12 , PLSTIRE

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015 PubMed
  2. Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V, Cdk6 contributes to cytoskeletal stability in erythroid cells., Haematologica, 102(6), 995-1005, 2017 PubMed
Created on 2019-12-09 14:11:40, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.