GeneID: 332

Description:
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. CDK6 is a key player in the differentiation of a variety of cell types, including osteoclasts, astrocytes, thymocytes and myeloid cells. CDK6 kinase activity is required for erythroid cytoskeletal organization/dynamics with effects on erythrocyte lifespan. Genetic variance in CDK6 gene associated with haematological parameters (e.g., white blood cell count).

Synonyms: MCPH12 , PLSTIRE

Comments:
N/A

Number of entries/variants: 1

1. Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015 PubMed
2. Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V, Cdk6 contributes to cytoskeletal stability in erythroid cells., Haematologica, 102(6), 995-1005, 2017 PubMed