GeneID: 33


Common Name: NOS2 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_011470.1 (NOS2A)
HUGO Symbol: NOS2 Full Name: nitric oxide synthase 2
Exons: 27 Introns: 26

Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase, which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. SNPs in this gene were found to be strongly associated with the HbF response to hydroxyurea (HU) in sickle cell patients.

Synonyms: HEP-NOS , iNOS , NOS , nitric oxide synthase 2, inducible , nitric oxide synthase 2A (inducible, hepatocytes) , NOS2A


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Publications / Origin

  1. Bloch KD, Wolfram JR, Brown DM, Roberts JD, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Jacob HJ, Bloch DB, Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17., Genomics , 27(3), 526-30, 1995 PubMed
  2. Rutherford S, Johnson MP, Curtain RP, Griffiths LR, Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension., Hum. Genet. , 109(4), 408-15, 2001 PubMed
  3. Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 13:53:08 (Show full history)

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