GeneID: 322



Names

Common Name: RAVER1 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NM_133452.3 (RAVER1)
HUGO Symbol: RAVER1 Full Name: ribonucleoprotein, PTB binding 1
Exons: 13 Introns: 12

Description:
The RAVER1 gene encodes a ribonucleoprotein, which interacts with the splicing regulator polypyrimidine tract-binding protein (PTB/hbRNPI). The mouse protein contains 3 RNA recognition motifs, 2 nuclear localization signals, and a Rev-like nuclear export sequence. Like PTB, it is localised within perinuclear structures that are engaged in RNA metabolism. It is also localised at microfilament plasma membrane attachment sites in fibroblasts, epithelial cells, and muscle. It exhibits ubiquitous but varying expression. Genetic variance in RAVER1 gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: KIAA1978

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Romanelli MG, Lorenzi P, Avesani F, Morandi C, Functional characterization of the ribonucleoprotein, PTB-binding 1/Raver1 promoter region., Gene, 405(1), 79-87, 2007 PubMed
  2. Lee JH, Rangarajan ES, Yogesha SD, Izard T, Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions., Structure, 17(6), 833-42, 2009 PubMed
  3. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
Created on 2019-11-29 12:00:50, Last reviewed on (Show full history)


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