GeneID: 320


Common Name: PDGFD Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NM_033135.4 (PDGFD)
HUGO Symbol: PDGFD Full Name: platelet derived growth factor D
Exons: 7 Introns: 6

This gene encodes a protein that belongs to the platelet-derived growth factor (PDGF) family of disulphide-bonded dimeric isoforms (e.g., PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD). These PDGFs are important for growth, survival and function in several types of connective tissue cell. PDGFD is secreted as a latent factor that requires activation by extracellular proteases. Genetic variance in PDGFD gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: SCDGF-B , MSTP036 , IEGF


Publications / Origin

  1. Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U, PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor., Nat. Cell Biol., 3(5), 512-6, 2001
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013
Created on 2019-11-29 11:04:13, Last reviewed on (Show full history)

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