GeneID: 320
Names
| Common Name: | PDGFD | Type: | Gene |
|---|---|---|---|
| Chromosome: | 11 (NC_000011.10) | Locus: | NM_033135.4 (PDGFD) |
| HUGO Symbol: | PDGFD | Full Name: | platelet derived growth factor D |
| Exons: | 7 | Introns: | 6 |
Description:
This gene encodes a protein that belongs to the platelet-derived growth factor (PDGF) family of disulphide-bonded dimeric isoforms (e.g., PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD). These PDGFs are important for growth, survival and function in several types of connective tissue cell. PDGFD is secreted as a latent factor that requires activation by extracellular proteases. Genetic variance in PDGFD gene associated with episodes of pain in patients with sickle cell disease.
Synonyms: SCDGF-B , MSTP036 , IEGF
Comments:
N/A
Number of entries/variants: 1
IthaScore
Sequence Viewer
Publications / Origin
- Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U, PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor., Nat. Cell Biol., 3(5), 512-6, 2001 PubMed
- Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2019-11-29 11:04:13 | The IthaGenes Curation Team | Created |