GeneID: 320



Names

Common Name: PDGFD Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NM_033135.4 (PDGFD)
HUGO Symbol: PDGFD Full Name: platelet derived growth factor D
Exons: 7 Introns: 6

Description:
This gene encodes a protein that belongs to the platelet-derived growth factor (PDGF) family of disulphide-bonded dimeric isoforms (e.g., PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD). These PDGFs are important for growth, survival and function in several types of connective tissue cell. PDGFD is secreted as a latent factor that requires activation by extracellular proteases. Genetic variance in PDGFD gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: SCDGF-B , MSTP036 , IEGF

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U, PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor., Nat. Cell Biol., 3(5), 512-6, 2001 PubMed
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
Created on 2019-11-29 11:04:13, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.