GeneID: 31


Common Name: FLT1 Type: Gene
Chromosome: 13 (NC_000013.11) Locus: NG_012003.1 (FLT1)
HUGO Symbol: FLT1 Full Name: fms related tyrosine kinase 1
Exons: 30 Introns: 29

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor (PGF), and plays an important role in angiogenesis and vasculogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Polymorphisms in this gene were found to be strongly associated with the HbF response to hydroxyurea (HU) in sickle cell patients.

Synonyms: FLT , fms-related tyrosine kinase 1 , vascular endothelial growth factor receptor 1 , VEGFR1


Publications / Origin

  1. Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M, Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family., Oncogene , 5(4), 519-24, 1990
  2. Herley MT, Yu Y, Whitney RG, Sato JD, Characterization of the VEGF binding site on the Flt-1 receptor., Biochem. Biophys. Res. Commun. , 262(3), 731-8, 1999
  3. Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007
  4. Sela S, Itin A, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Yagel S, Keshet E, A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia., Circ. Res. , 102(12), 1566-74, 2008
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 14:13:44 (Show full history)

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