GeneID: 307


Common Name: TGFA-ADD2 Type: Intergenic Region
Chromosome: 2 (NC_000002.12) Locus: N/A
HUGO Symbol: TGFA-ADD2 Full Name: N/A
Exons: N/A Introns: N/A

TGFA (transforming growth factor alpha) encodes a ligand for the epidermal growth factor receptor, which activates a signalling pathway for cell proliferation, differentiation and development. ADD2 (adducin 2) belongs to a family of membrane cytoskleleton-associated proteins that promote the assembly of the spectrin-actin network. Adducins are involved in signal transduction in various cellular functions upon regulation by protein kinase C-dependent and calcium/calmodulin-dependent pathways. Adducin 2 is expressed during early erythropoiesis and at sites of cell-cell contact in epithelial tissues. Genetic variance in the TGFA-ADD2 intergenic region associated with painful episodes in patients with sickle cell disease.

Synonyms: N/A


External Links

Sequence Viewer

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Publications / Origin

  1. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
  3. Kiang KM, Leung GK, A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer., Biomed Res Int, 2018(0), 3465929, 2018 PubMed
Created on 2019-10-17 09:54:26, Last reviewed on (Show full history)

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