GeneID: 300

Description:
The NPY gene encodes neuropeptide Y, which is widely expressed in the central and peripheral nervous systems. It functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. It plays a central role in nociceptive signalling in inflammatory and neuropathic pain and it appears to influence many biological processes, including cortical excitability, energy homeostasis, obesity, anorexia and drug addiction. Genetic variance in NPY gene associated with acute chest syndrome (ACS) in patients with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: PYY4

Comments:
N/A

Number of entries/variants: 1

1. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
3. Diaz-delCastillo M, Woldbye DPD, Heegaard AM, Neuropeptide Y and its Involvement in Chronic Pain., Neuroscience, 387(0), 162-169, 2018 PubMed