GeneID: 295

Names

Common Name:	CHL1-LINC01266	Type:	Intergenic Region
Chromosome:	3 (NC_000003.12)	Locus:	N/A
HUGO Symbol:	CHL1-LINC01266	Full Name:	N/A
Exons:	N/A	Introns:	N/A

Description:
The CHL1 gene encodes a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. LINC01266 is a non-protein coding RNA. Variation in this intergenic region (CHL1-LINC01266) associated with acute chest syndrome (ACS) in patients with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 1

External Links

No available links

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Publications / Origin

Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed

Created on 2019-10-03 11:20:28, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2019-10-03 11:20:28	The IthaGenes Curation Team	Created

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