GeneID: 291


Common Name: CTXND2 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NR_148929.1 (CTXND2)
HUGO Symbol: CTXND2 Full Name: cortexin domain containing 2
Exons: 2 Introns: 1

Cortexin domain containing 2 (CTXND2) is a long non-coding RNA (lncRNA). lncRNAs play a role in the regulation of gene expression. Cortexin is a neuron-specific membrane protein and variations in CTXND2 have been associated with neoplastic disease. A variation in this gene has been associated with acute chest syndrome (ACS) in cohorts with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: N/A


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Publications / Origin

  1. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
  3. Ransohoff KJ, Wu W, Cho HG, Chahal HC, Lin Y, Dai HJ, Amos CI, Lee JE, Tang JY, Hinds DA, Han J, Wei Q, Sarin KY, Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma., Oncotarget, 8(11), 17586-17592, 2017 PubMed
Created on 2019-10-02 12:20:29, Last reviewed on (Show full history)

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