GeneID: 290
Names
Common Name: | IGF2BP1 | Type: | Gene |
---|---|---|---|
Chromosome: | 17 (NC_000017.11) | Locus: | NG_030585.1 (IGF2BP1) |
HUGO Symbol: | IGF2BP1 | Full Name: | insulin like growth factor 2 mRNA binding protein 1 |
Exons: | 15 | Introns: | 14 |
Description:
This gene encodes an RNA binding protein that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. IGF2BP1 was demonstrated to regulate fetal-to adult developmental transition in human erythroblasts. IGF2BP1 is a target of the lethal-7 (let-7) miRNA family, such that IGF2BP1 is expressed during early development and steadily decreases after birth in most tissues. Overexpression of IGF2BP1 in cultured human adult erythroblasts from beta-thalassaemia and healthy donors resulted in elevated HbF levels. Similarly, IGF2BP1 suppressed βS-globin and increased γ-globin expression in SCD patient-derived erythroblasts. IGF2BP1 promotes Interaction between the βLCR andγ-globin genes. IGF2BP1 is a regulator of BCL11A and HMGA2, which are both implicated in the modulation of Hb F expression.
Synonyms: IMP1 , ZBP1 , CRDBP , IMP-1 , CRD-BP , VICKZ1
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- de Vasconcellos JF, Lee YT, Byrnes C, Tumburu L, Rabel A, Miller JL, HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts., PLoS ONE, 11(11), e0166928, 2016
- de Vasconcellos JF, Tumburu L, Byrnes C, Lee YT, Xu PC, Li M, Rabel A, Clarke BA, Guydosh NR, Proia RL, Miller JL, IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts., Proc. Natl. Acad. Sci. U.S.A., 114(28), E5664-E5672, 2017
A/A | Date | Curator(s) | Comments |
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1 | 2019-09-30 15:57:53 | The IthaGenes Curation Team | Created |
2 | 2020-03-16 15:13:15 | The IthaGenes Curation Team | Reviewed. Comment updated. |