GeneID: 290



Names

Common Name: IGF2BP1 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_030585.1 (IGF2BP1)
HUGO Symbol: IGF2BP1 Full Name: insulin like growth factor 2 mRNA binding protein 1
Exons: 15 Introns: 14

Description:
This gene encodes an RNA binding protein that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. IGF2BP1 was demonstrated to regulate fetal-to adult developmental transition in human erythroblasts. IGF2BP1 is a target of the lethal-7 (let-7) miRNA family, such that IGF2BP1 is expressed during early development and steadily decreases after birth in most tissues. Overexpression of IGF2BP1 in cultured human adult erythroblasts from beta-thalassaemia and healthy donors resulted in elevated HbF levels. Similarly, IGF2BP1 suppressed βS-globin and increased γ-globin expression in SCD patient-derived erythroblasts. IGF2BP1 promotes Interaction between the βLCR andγ-globin genes. IGF2BP1 is a regulator of BCL11A and HMGA2, which are both implicated in the modulation of Hb F expression.

Synonyms: IMP1 , ZBP1 , CRDBP , IMP-1 , CRD-BP , VICKZ1

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. de Vasconcellos JF, Lee YT, Byrnes C, Tumburu L, Rabel A, Miller JL, HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts., PLoS ONE, 11(11), e0166928, 2016 PubMed
  2. de Vasconcellos JF, Tumburu L, Byrnes C, Lee YT, Xu PC, Li M, Rabel A, Clarke BA, Guydosh NR, Proia RL, Miller JL, IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts., Proc. Natl. Acad. Sci. U.S.A., 114(28), E5664-E5672, 2017 PubMed
Created on 2019-09-30 15:57:53, Last reviewed on 2020-03-16 15:13:15 (Show full history)


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