GeneID: 29
Names
| Common Name: | TOX | Type: | Gene |
|---|---|---|---|
| Chromosome: | 8 (NC_000008.11) | Locus: | NG_011993.1 (TOX) |
| HUGO Symbol: | TOX | Full Name: | thymocyte selection associated high mobility group box |
| Exons: | 9 | Introns: | 8 |
Description:
The protein encoded by this gene contains a HMG box DNA binding domain. The encoded protein binds to DNA in the minor groove and might control gene expression through changing local chromatin structure and modulating the formation of transcriptional regulatory complexes. This protein may function to regulate T-cell development. Polymorphisms in this gene were associated with HbF levels in cohorts with sickle cell anaemia, as well as with HbF response to hydroxyurea treatment.
Synonyms: TOX1 , KIAA0808
Comments:
N/A
Number of entries/variants: 23
Sequence Viewer
Publications / Origin
- Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J, TOX: an HMG box protein implicated in the regulation of thymocyte selection., Nat. Immunol. , 3(3), 272-80, 2002 PubMed
- Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007 PubMed
- Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations., Am. J. Hematol. , 83(3), 189-95, 2008 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2014-04-01 14:19:10 | The IthaGenes Curation Team | Created |
| 2 | 2014-04-10 20:14:27 | The IthaGenes Curation Team | Reviewed. Description, synonyms and links added. |
| 3 | 2014-04-11 09:36:29 | The IthaGenes Curation Team | Reviewed. References added. |
| 4 | 2016-04-28 14:06:13 | The IthaGenes Curation Team | Reviewed. |