GeneID: 284


Common Name: IL18 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_028143.1 (IL18)
HUGO Symbol: IL18 Full Name: interleukin 18
Exons: 6 Introns: 5

The encoded protein is a member of the interleukin 1 (IL-1) cytokine family, which is involved in numerous immunological responses. IL18 is processed from its 23 kDa proform by caspase-1 into its 18 kDa active form, and is best known for its capacity to stimulate interferon gamma production. Increased levels of circulating IL18 have been associated with development of heart failure. IL18 has been associated with decreased left ventricular contractility and myocardial relaxation in both mice and humans, possibly via p38 MAPK. Also, IL18 has been associated with diastolic dysfunction in patients with sickle cell disease (SCD), following experimental validation in a mouse SCD model.

Synonyms: IGIF , IL-18 , IL-1g , IL1F4


Sequence Viewer

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Publications / Origin

  1. Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T, Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice., Am. J. Physiol. Heart Circ. Physiol., 289(2), H708-14, 2005 PubMed
  2. Toldo S, Mezzaroma E, O'Brien L, Marchetti C, Seropian IM, Voelkel NF, Van Tassell BW, Dinarello CA, Abbate A, Interleukin-18 mediates interleukin-1-induced cardiac dysfunction., Am. J. Physiol. Heart Circ. Physiol., 306(7), H1025-31, 2014 PubMed
  3. Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF, Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease., PLoS ONE , 11(9), e0163013, 2016 PubMed
  4. Fields JK, Günther S, Sundberg EJ, Structural Basis of IL-1 Family Cytokine Signaling., Front Immunol, 10(0), 1412, 2019 PubMed
Created on 2019-09-30 14:09:08, Last reviewed on (Show full history)

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