GeneID: 281

Description:
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases (ACs) that is soluble and insensitive to G protein or forskolin regulation. Soluble AC (sAC) is encoded by a single functional sAC gene, the ADCY10. ACs catalyse the conversion of ATP to the second messenger cyclic AMP (cAMP) that mediates numerous biological responses, including transcriptional regulation, metabolism and cell migration. In contrast to membrane-associated AC, sAC is thought to generate cAMP closer to its required site of action. sAC activity requires divalent metal cations in the catalytic active site of the enzyme in order to coordinate the binding and cyclizing of ATP and it is also uniquely activated through bicarbonate binding. sAC is implicated in the regulation of cell growth, particularly in hyperplasia, and plays a central role in sperm physiology. sAC contributes to the regulation of CREB-mediated Na+/K+-ATPase expression in the vascular endothelium and is an important regulator of endothelial stiffness. A variation in ADCY10 associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: SAC , HCA2 , SACI , Sacy , hsAC , HEL-S-7a

Comments:
N/A

Number of entries/variants: 1

1. Buck J, Sinclair ML, Schapal L, Cann MJ, Levin LR, Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals., Proc. Natl. Acad. Sci. U.S.A., 96(1), 79-84, 1999 PubMed
2. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
3. Pozdniakova S, Ladilov Y, Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments., J Cardiovasc Dev Dis, 5(2), , 2018 PubMed