GeneID: 28
Names
| Common Name: | PDE7B | Type: | Gene |
|---|---|---|---|
| Chromosome: | 6 (NC_000006.12) | Locus: | NG_011994.1 (PDE7B) |
| HUGO Symbol: | PDE7B | Full Name: | Phosphodiesterase 7B |
| Exons: | 13 | Introns: | 12 |
Description:
Phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP, cyclic nucleotides that play important roles as second messengers in multiple physiologic processes. PDE7B belongs to the large superfamily of PDEs, which can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Polymorphisms in this gene were found to be strongly associated with the HbF response to hydroxyurea (HU) in sickle cell patients.
Synonyms: bA472E5.1
Comments:
N/A
Number of entries/variants: 6
Publications / Origin
- Hetman JM, Soderling SH, Glavas NA, Beavo JA, Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase., Proc. Natl. Acad. Sci. U.S.A. , 97(1), 472-6, 2000
- Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007