GeneID: 28


Common Name: PDE7B Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_011994.1 (PDE7B)
HUGO Symbol: PDE7B Full Name: Phosphodiesterase 7B
Exons: 13 Introns: 12

Phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP, cyclic nucleotides that play important roles as second messengers in multiple physiologic processes. PDE7B belongs to the large superfamily of PDEs, which can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Polymorphisms in this gene were found to be strongly associated with the HbF response to hydroxyurea (HU) in sickle cell patients.

Synonyms: bA472E5.1


Publications / Origin

  1. Hetman JM, Soderling SH, Glavas NA, Beavo JA, Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase., Proc. Natl. Acad. Sci. U.S.A. , 97(1), 472-6, 2000
  2. Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 14:01:54 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.