GeneID: 279


Common Name: MARCHF10 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NM_001288779.2 (MARCHF10)
HUGO Symbol: MARCHF10 Full Name: membrane associated ring-CH-type finger 10
Exons: 12 Introns: 11

MARCHF10 is a member of the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases. MARCH enzymes add ubiquitin to target lysines in substrate proteins, thereby signalling their vesicular transport between membrane compartments. In contrast to other members of the MARCH family, MARCHF10 has no predicted transmembrane structures and the (amino-terminal) C3HC4-type RING-finger domain appears closer to the C-terminal end of the protein. MARCHF10 is highly expressed in the testis and is required for spermatid maturation. A variation in MARCHF10 associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: RNF190 , MARCH-X , MARCH10


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Publications / Origin

  1. Iyengar PV, Hirota T, Hirose S, Nakamura N, Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella., J. Biol. Chem., 286(45), 39082-90, 2011 PubMed
  2. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
  3. Samji T, Hong S, Means RE, The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell., Int Sch Res Notices, 2014(0), 637295, 2014 PubMed
Created on 2019-09-26 11:26:53, Last reviewed on (Show full history)

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