GeneID: 276


Common Name: TTLL10 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NM_001130045.2 (TTLL10)
HUGO Symbol: TTLL10 Full Name: tubulin tyrosine ligase like 10
Exons: 16 Introns: 15

The encoded protein belongs to the tubulin tyrosine ligase-like (TTLL) family with important functions in protein post-translational modifications. TTLL10 is an elongating glycylase, that is, it mediates the elongation of glycine residues added on proteins by initiating enzymes. It was discovered to catalyze tubulin glycylation, which mostly occurs on motile cilia and flagella. Glycophorins are transmembrane proteins of erythrocytes with roles in the regulation of membrane mechanical properties and maintenance of shape. A variation in TTLL10 associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: TTLL5


Sequence Viewer

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Publications / Origin

  1. Chasis JA, Mohandas N, Red blood cell glycophorins., Blood, 80(8), 1869-79, 1992 PubMed
  2. Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, Thomas D, Bré MH, Van Dorsselaer A, Gaertig J, Janke C, Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation., Cell, 137(6), 1076-87, 2009 PubMed
  3. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
  4. Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bièche I, Rusconi F, Janke C, Tubulin glycylation controls primary cilia length., J. Cell Biol., 216(9), 2701-2713, 2017 PubMed
Created on 2019-09-25 11:54:13, Last reviewed on (Show full history)

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