GeneID: 271

Description:
The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (oxLDL). It is involved in the recognition, internalization and degradation of oxLDL by vascular endothelial cells. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. This gene is regulated through the cyclic AMP signalling pathway. A signalling pathway that involves nitric oxide synthase (NOS), NO and flow-induced ATP has been implicated in the regulation of hydroxyurea-induced Hb F. A variation in OLR1 associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: LOX1 , LOXIN , SLOX1 , CLEC8A , SCARE1

Comments:
N/A

Number of entries/variants: 1

1. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T, An endothelial receptor for oxidized low-density lipoprotein., Nature, 386(6620), 73-7, 1997 PubMed
2. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
3. Pule GD, Mowla S, Novitzky N, Wiysonge CS, Wonkam A, A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease., Expert Rev Hematol, 8(5), 669-79, 2015 PubMed