GeneID: 259



Names

Common Name: ZHX2 Type: Gene
Chromosome: 8 (NC_000008.11) Locus: NG_046951.1 (ZHX2)
HUGO Symbol: ZHX2 Full Name: zinc fingers and homeoboxes 2
Exons: 4 Introns: 3

Description:
Zinc fingers and homeoboxes 2 (ZHX2) gene belongs to the ZHX transcriptional repressor family. Similar to other ZHX proteins, ZHX2 contains two N-terminal Cys2-His2-type zinc finger motifs and five C-terminal homeodomains. It is capable of forming homodimers, as well as heterodimers with other ZHX family members. It interacts with the activation domain of the A subunit of nuclear factor-Y (NF-YA), which is involved in the transcriptional regulation of a variety of genes. ZHX2 has been implicated in cell cycle control, as well as in the regulation of globin genes and the increased levels of γ-globin in hereditary persistence of fetal hemoglobin (HPFH). Although evidence is conflicting, a study conducted among South Indian β-thalassaemia patients revealed a non-significant association between a genetic variant of ZHX2 and haemoglobin F (HbF) levels.

Synonyms: RAF , AFR1

Comments:
N/A

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Publications / Origin

  1. Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K, Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor., Biochem. J., 373(0), 747-57, 2003 PubMed
  2. Perincheri S, Dingle RW, Peterson ML, Spear BT, Hereditary persistence of alpha-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene., Proc. Natl. Acad. Sci. U.S.A., 102(2), 396-401, 2005 PubMed
  3. de Andrade TG, Peterson KR, Cunha AF, Moreira LS, Fattori A, Saad ST, Costa FF, Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster., Blood Cells Mol. Dis., 37(2), 82-90, 2006 PubMed
  4. Munshi A, Dadheech S, Jain S, Joseph J, Al-Hazzani A, Alshatwi AA, Sai Babu M, Rajeshwar K, Jyothy A, Lack of association of G779A ZHX-2 gene variant with HbF levels in β-thalassemia major., Eur. J. Haematol., 86(6), 502-6, 2011 PubMed
Created on 2019-03-19 12:24:51, Last reviewed on (Show full history)


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