GeneID: 258

Description:
TRPA1 is a member of the transient receptor potential (TRP) family of ion channels that act as sensors of a wide range of cellular and environmental signals and mediate pain sensitivity. There are seven TRP protein sub-families; TRPA (ankyrin), TRPV (vanilloid), TRPC (canonical), TRPP (polycystin), TRPM (melastatin), TRPML (mucolipin), and TRPN (NOMPC-like; only in invertebrates and fish). TRP channels contain six-transmembrane polypeptide subunits forming tetramers with a central ion conducting pore. TRPA1 also has 17 ankyrin repeats in the N-terminal region. The TRPA1 receptor is activated by diverse sensory processes, including noxious cold (17 °C), pungent ingredients of natural products (e.g., cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger), environmental irritants (e.g., acrolein), and inflammatory agents (e.g., bradykinin). TRPA1 function is modulated by phospholipase C activity. TRPA1 is expressed in small-diameter neurons of the trigeminal and dorsal root ganglia (DRGs), as well as in the hair cells of the inner ear. TRPA1 plays a major role in the generation and/or maintenance of inflammatory and neuropathic pain. It is implicated in the etiology of familial episodic syndrome (FEPS). Genetic variants of TRPA1 associated with utilization rate in sickle cell disease (SCD), i.e., the number of emergency department/acute care center admissions as a result of SCD pain crisis.

Synonyms: FEPS , FEPS1 , ANKTM1

Comments:
N/A

Number of entries/variants: 1

1. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A, Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin., Neuron, 41(6), 849-57, 2004 PubMed
2. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D, TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents., Cell, 124(6), 1269-82, 2006 PubMed
3. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP, TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction., Neuron, 50(2), 277-89, 2006 PubMed
4. Cortright DN, Szallasi A, TRP channels and pain., Curr. Pharm. Des., 15(15), 1736-49, 2009 PubMed
5. Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D, Structure of the TRPA1 ion channel suggests regulatory mechanisms., Nature, 525(7570), 552, 2015 PubMed
6. Jhun EH, Hu X, Sadhu N, Yao Y, He Y, Wilkie DJ, Molokie RE, Wang ZJ, Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease., Pharmacogenomics, 19(5), 401-411, 2018 PubMed