GeneID: 250


Common Name: ITGA11 Type: Gene
Chromosome: 15 (NC_000015.10) Locus: NG_046911.1 (ITGA11)
HUGO Symbol: ITGA11 Full Name: integrin subunit alpha 11
Exons: 30 Introns: 29

The ITGA11 gene encodes an integrin α-subunit. Integrins are transmembrane receptors composed of one α- and one β-subunit. The integrin family consists of 18 α- and 8 β-subunits that can assemble into 24 different heterodimers of distinct ligand-binding specificity and tissue distribution. The encoded protein contains an I domain (also called the A domain), which is central in ligand binding. ITGA11 facilitates the movement of cells through a collagen-rich extracellular matrix. It is expressed mainly in regions of forming cartilage, bone, invertebral discs and cornea during development, and dimerizes with the β1-subunit to form the collagen receptor α11β1. It binds type I and type IV collagen. Collagen receptors (α1β1, α2β1, α10β1, and α11β1) are involved in various biological processes, including mesenchymal stem cell proliferation, wound healing, and innate and acquired immunity. ITGA11 plays a role in myofibroblast differentiation with implications for fibrotic disease, and is regulated by the hedgehog signalling pathway. It is needed in the periodontal ligament to facilitate the movement of periodontal ligament fibroblasts and the reorganization of collagen during tooth eruption. It may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. An ITGA11 variant associated with leukocytosis in sickle cell anaemia.

Synonyms: HsT18964


Sequence Viewer

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Publications / Origin

  1. Heino J, The collagen family members as cell adhesion proteins., Bioessays, 29(10), 1001-10, 2007 PubMed
  2. Popova SN, Barczyk M, Tiger CF, Beertsen W, Zigrino P, Aszodi A, Miosge N, Forsberg E, Gullberg D, Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor., Mol. Cell. Biol., 27(12), 4306-16, 2007 PubMed
  3. Barczyk M, Bolstad AI, Gullberg D, Role of integrins in the periodontal ligament: organizers and facilitators., Periodontol. 2000, 63(1), 29-47, 2013 PubMed
  4. Schaefer BA, Flanagan JM, Alvarez OA, Nelson SC, Aygun B, Nottage KA, George A, Roberts CW, Piccone CM, Howard TA, Davis BR, Ware RE, Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia., PLoS ONE , 11(10), e0164364, 2016 PubMed
  5. Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman SL, Hoshida Y, Prakash J, Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases., Exp. Mol. Med., 49(11), e396, 2017 PubMed
Created on 2019-03-19 11:29:04, Last reviewed on (Show full history)

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