GeneID: 24


Common Name: CD81 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_023386.1 (CD81)
HUGO Symbol: CD81 Full Name: CD81 molecule
Exons: 8 Introns: 7

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. CD81 is a cell surface glycoprotein that is known to form complexes with integrins. CD81 encodes a molecule involved in the signal modulation of B lymphocytes and appears to promote muscle cell fusion and support myotube maintenance. The gene is localized in a tumor-suppressor gene region and is thus considered a candidate gene for malignancies. It may play an important role in the regulation of lymphoma cell growth. Polymorphisms in the CD81 gene showed strong association with alloimmunization in sickle cell patients.

Synonyms: TAPA-1 , TSPAN28


Sequence Viewer

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Publications / Origin

  1. Andria ML, Hsieh CL, Oren R, Francke U, Levy S, Genomic organization and chromosomal localization of the TAPA-1 gene., J. Immunol. , 147(3), 1030-6, 1991 PubMed
  2. Tatari-Calderone Z, Tamouza R, Le Bouder GP, Dewan R, Luban NL, Lasserre J, Maury J, Lionnet F, Krishnamoorthy R, Girot R, Vukmanovic S, The association of CD81 polymorphisms with alloimmunization in sickle cell disease., Clin. Dev. Immunol. , 2013(65535), 937846, 2013 PubMed
  3. Levy S, Function of the tetraspanin molecule CD81 in B and T cells., Immunol. Res. , 2014 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 13:16:00 (Show full history)

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