GeneID: 238



Names

Common Name: FCGR2C Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_011982.1 (FCGR2C)
HUGO Symbol: FCGR2C Full Name: Fc fragment of IgG receptor IIc (gene/pseudogene)
Exons: 7 Introns: 6

Description:
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors (FcγRs) found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. It also plays a crucial role in the formation of allo-antibodies. An allelic polymorphism in this gene results in both coding and non-coding variants. The non-classical open reading frame in the FCGR2C gene (FCGR2C.nc-ORF polymorphism) was associated with a decreased red blood cell allo-immunization risk in patients with sickle cell disease.

Synonyms: CD32 , FCG2 , CD32C , CDW32 , IGFR2 , FCRIIC

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Su K, Wu J, Edberg JC, McKenzie SE, Kimberly RP, Genomic organization of classical human low-affinity Fcgamma receptor genes., Genes Immun. , 3(0), S51-6, 2002 PubMed
  2. Meinderts SM, Sins JWR, Fijnvandraat K, Nagelkerke SQ, Geissler J, Tanck MW, Bruggeman C, Biemond BJ, Rijneveld AW, Kerkhoffs JH, Pakdaman S, Habibi A, van Bruggen R, Kuijpers TW, Pirenne F, van den Berg TK, Non-classical FCGR2C haplotype is associated with protection from red blood cell allo-immunization in sickle cell disease., Blood , 2017 PubMed
Created on 2017-11-07 20:12:26, Last reviewed on (Show full history)


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