GeneID: 23

Description:
The encoded protein functions as a stress-response protein and plays an essential role in heme catabolism. It confers cytoprotective activity since free heme can sensitize cells to undergo apoptosis. Heme oxygenase-1 (HO-1) cleaves free heme to form biliverdin, ferrous iron, and carbon monoxide. Biliverdin is converted to bilirubin by biliverdin reductase for excretion in bile. The activity of HO-1 is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. In addition to heme, HO-1 is induced by a variety of non-heme inducers, such as heavy metals, endotoxin, heat shock, inflammatory cytokines and prostaglandins, indicating that HO-1 is essential in maintaing cellular homeostasis. Polymorphisms in the HMOX1 gene associated with nephropathy, as well as with HbF levels in sickle cell disease.

Synonyms: bK286B10 , HO-1 , HSP32 , HMOX1D , bK286B10 ,

Comments:
N/A

Number of entries/variants: 4

1. Yoshida T, Biro P, Cohen T, Müller RM, Shibahara S, Human heme oxygenase cDNA and induction of its mRNA by hemin., Eur. J. Biochem. , 171(3), 457-61, 1988
2. Choi AM, Alam J, Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury., Am. J. Respir. Cell Mol. Biol. , 15(1), 9-19, 1996
3. Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM, Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice., J. Clin. Invest. , 116(3), 808-16, 2006
4. Gozzelino R, Jeney V, Soares MP, Mechanisms of cell protection by heme oxygenase-1., Annu. Rev. Pharmacol. Toxicol. , 50(0), 323-54, 2010
5. Bean CJ, Boulet SL, Ellingsen D, Pyle ME, Barron-Casella EA, Casella JF, Payne AB, Driggers J, Trau HA, Yang G, Jones K, Ofori-Acquah SF, Hooper WC, DeBaun MR, Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease., Blood , 120(18), 3822-8, 2012
6. Gil GP, Ananina G, Oliveira MB, Costa FF, Silva MJ, Santos MN, Bezerra MA, Hatzlhofer BL, Araujo AS, Melo MB, Polymorphism in the HMOX1 gene is associated with high levels of fetal hemoglobin in Brazilian patients with sickle cell anemia., Hemoglobin , 37(4), 315-24, 2013
7. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013
8. Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JA, Gladwin MT, Singh AK, Gordeuk VR, Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy., Haematologica , 100(10), 1275-84, 2015