GeneID: 227


Common Name: KLF10 Type: Gene
Chromosome: 8 (NC_000008.11) Locus: NG_033271.1 (KLF10)
HUGO Symbol: KLF10 Full Name: Kruppel like factor 10
Exons: 4 Introns: 3

The KLF10 gene encodes a member of the family of Krüppel-like zinc finger transcription factors that feature C2H2-type zinc finger domains. All members of this family bind to GC-rich Sp1-like sequences to regulate gene transcription. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta (TGF-β) signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. It has been proposed to be involved in the regulation of fetal haemoglobin (HbF), acting indirectly to modify fetal globin synthesis. It plays an important role in ameliorating the response to hydroxyurea therapy and, hence, the disease phenotype of β-haemoglobinopathies. Alternative splicing results in multiple transcript variants.

Synonyms: EGRA , TIEG , TIEG1 , EGR-alpha


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Publications / Origin

  1. Subramaniam M, Hawse JR, Rajamannan NM, Ingle JN, Spelsberg TC, Functional role of KLF10 in multiple disease processes., Biofactors , 36(1), 8-18, 2010 PubMed
  2. Gravia A, Chondrou V, Kolliopoulou A, Kourakli A, John A, Symeonidis A, Ali BR, Sgourou A, Papachatzopoulou A, Katsila T, Patrinos GP, Correlation of SIN3A genomic variants with β-hemoglobinopathies disease severity and hydroxyurea treatment efficacy., Pharmacogenomics , 2016 PubMed
  3. Elalfy MS, El Sherif NH, Kamal TM, Aly NH, Klf10 Gene, a Secondary Modifier and a Pharmacogenomic Biomarker of Hydroxyurea Treatment Among Patients With Hemoglobinopathies., J. Pediatr. Hematol. Oncol. , 39(3), e155-e162, 2017 PubMed
Created on 2017-03-28 12:45:31, Last reviewed on (Show full history)

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