GeneID: 226
Names
| Common Name: | CD163 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 12 (NC_000012.12) | Locus: | NG_029826.1 (CD163) |
| HUGO Symbol: | CD163 | Full Name: | CD163 molecule |
| Exons: | 17 | Introns: | 16 |
Description:
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A polymorphism in this gene associated with glomerular filtration rate in pediatric patients with sickle cell disease.
Synonyms: M130 , MM130 , SCARI1
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A, CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin., Blood , 107(1), 373-80, 2006
- Schaer CA, Schoedon G, Imhof A, Kurrer MO, Schaer DJ, Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin., Circ. Res. , 99(9), 943-50, 2006
- Schaefer BA, Flanagan JM, Alvarez OA, Nelson SC, Aygun B, Nottage KA, George A, Roberts CW, Piccone CM, Howard TA, Davis BR, Ware RE, Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia., PLoS ONE , 11(10), e0164364, 2016