GeneID: 225


Common Name: CYP4B1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_007939.1 (CYP4B1)
HUGO Symbol: CYP4B1 Full Name: cytochrome P450 family 4 subfamily B member 1
Exons: 12 Introns: 11

CYP4B1 is a member of the cytochrome P450 (CYP450) superfamily of heme-thiolate proteins that catalyze mono-oxygenase reactions and partake in the metabolism of a wide range of endogenous and xenobiotic compounds, such as lipids, steroids and drugs. The CYP4 proteins are primarily involved in fatty acid metabolism, and possess ω-hydroxylation activity. CYP4B1 is distinguished from other family members by its increased capacity to catalyze ω-hydroxylation of smaller fatty-acids and n-alkanes. It is predominantly expressed in the lung, with low levels in the heart, skeletal muscle and kidney. A long non-coding RNA (lncRNA) of CYP4B1 has been associated with diabetic nephropathy pathogenesis. A polymorphism in this gene associated with glomerular filtration rate in pediatric patients with sickle cell disease.

Synonyms: CYPIVB1 , P-450HP


Publications / Origin

  1. Baer BR, Rettie AE, CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism., Drug Metab. Rev. , 38(3), 451-76, 2006
  2. Schaefer BA, Flanagan JM, Alvarez OA, Nelson SC, Aygun B, Nottage KA, George A, Roberts CW, Piccone CM, Howard TA, Davis BR, Ware RE, Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia., PLoS ONE , 11(10), e0164364, 2016
  3. Wang M, Wang S, Yao D, Yan Q, Lu W, A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy., Mol. Cell. Endocrinol. , 426(0), 136-45, 2016
  4. Hsu MH, Baer BR, Rettie AE, Johnson EF, The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monoxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation., J. Biol. Chem. , 2017
Created on 2017-03-21 14:01:27, Last reviewed on (Show full history)

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