GeneID: 214


Names

Common Name: CCND3 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_041939.1 (CCND3)
HUGO Symbol: CCND3 Full Name: cyclin D3
Exons: 5 Introns: 4

Description:
This gene encodes cyclin D3, a member of the family of D-type cyclins with critical functions in cell cycle regulation. D-type cyclins are core components of the cell cycle apparatus and are induced by mitogen stimulation. D-cyclins form a complex with and function as a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. These D-cyclin/CDK complexes interact with and phosphorylate the retinoblastoma tumor suppressor protein (Rb) and Rb-related p107 and p130 proteins, resulting in the release of E3F transcription factors that promote cell cycle G1/S transition. Cyclin D3 plays a critical role in regulating the number of cell divisions during erythroid differentiation, thus controlling erythrocyte size and number. Deregulation of the CCND3 gene has been linked to cancers of haematopoietic origin.

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 2

IthaScore

Publications / Origin

  1. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P, Mouse development and cell proliferation in the absence of D-cyclins., Cell , 118(4), 477-91, 2004
  2. Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF, Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number., Genes Dev. , 26(18), 2075-87, 2012
  3. Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F, Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels., Nat. Genet. , 47(11), 1264-71, 2015
Created on 2017-02-20 14:39:59, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.