GeneID: 213
Names
| Common Name: | FOG1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 16 (NC_000016.10) | Locus: | N/A |
| HUGO Symbol: | ZFPM1 | Full Name: | zinc finger protein, FOG family member 1 |
| Exons: | 10 | Introns: | 9 |
Description:
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. Mutations that abrogate the GATA/FOG interaction have been associated with familial dyserythropoietic anaemia and thrombocytopenia.
Synonyms: FOG , ZNF408 , ZNF89A , ZC2HC11A
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F, Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels., Nat. Genet. , 47(11), 1264-71, 2015