GeneID: 199


Common Name: GSTT1 Type: Gene
Chromosome: 22 (NC_000022.11) Locus: N/A
HUGO Symbol: GSTT1 Full Name: glutathione S-transferase theta 1
Exons: 5 Introns: 4

GSTT1 is a member of the glutathione S-transferase (GST) family of detoxification enzymes, which catalyse conjugation reactions between the reduced form of glutathione (a nucleophile) and a variety of electrophilic compounds, such as environmental toxins and carcinogens. The glutathione system protects cells against damage from oxidative stress by reducing oxygen-free radicals. As oxidative stress would promote sickling of HbS, genetic polymorphisms of GSTs are expected to modulate the phenotype and/or severity of sickle cell disease (SCD). GSTs are encoded by polymorphic genes divided into five classes: α, ζ, μ, π, and θ. The GSTT1 gene encodes a GST that belongs to the θ class. The null GSTT1 genotype has been linked with carcinogenesis, as well as with an increased risk of developing SCD. It also associated with hemolysis/hepatic (i.e. total and indirect bilirubin levels) laboratory markers in SCA patients treated with hydroxyurea. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.

Synonyms: N/A


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Strange RC, Spiteri MA, Ramachandran S, Fryer AA, Glutathione-S-transferase family of enzymes., Mutat. Res. , 482(1), 21-6, 2001 PubMed
  2. Abu-Duhier F, Mir R, GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia., Hematology , 2016 PubMed
  3. Yahouédéhou SCMA, Carvalho MOS, Oliveira RM, Santiago RP, da Guarda CC, Carvalho SP, Ferreira JRD, Aleluia MM, Adorno EV, Gonçalves MS, Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters., Dis. Markers, 2018(0), 6105691, 2018 PubMed
Created on 2017-01-24 10:14:58, Last reviewed on 2020-09-17 10:55:54 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.