GeneID: 197


Common Name: CD36 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_008192.1 (CD36)
HUGO Symbol: CD36 Full Name: CD36 molecule
Exons: 14 Introns: 13

This gene encodes an 88-kDa cell surface glycoprotein expressed on a wide variety of cell types, including platelets, monocytes, microvascular endothelial cells, and erythrocytes, among others. It acts as a receptor for extracellular matrix proteins such as type I collagen and thrombospondin (TSP). Since the latter constitutes a group of widely distributed proteins involved in a variety of adhesive processes, the encoded protein may have important functions as a cell adhesion molecule. It can form a complex with both TSP and αVβ3 (endothelial integrin) to mediate adhesion of sickle erythrocytes to vascular endothelium, thereby contributing to vaso-occlusion in sickle cell disease. Sickle erythrocytes from patients on hydroxyurea therapy have been shown to exhibit a reduced surface expression of CD36 with a concomitant decrease in adhesive properties. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene.

Synonyms: FAT , GP4 , GP3B , GPIV , CHDS7 , PASIV , SCARB3 , BDPLT10


Publications / Origin

  1. Lawler J, Weinstein R, Hynes RO, Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors., J. Cell Biol. , 107(6), 2351-61, 1988
  2. Fernández-Ruiz E, Armesilla AL, Sánchez-Madrid F, Vega MA, Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2., Genomics , 17(3), 759-61, 1993
  3. Gambero S, Canalli AA, Traina F, Albuquerque DM, Saad ST, Costa FF, Conran N, Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties., Eur. J. Haematol. , 78(2), 144-51, 2007
  4. Finnegan EM, Barabino GA, Liu XD, Chang HY, Jonczyk A, Kaul DK, Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion., Am. J. Physiol. Heart Circ. Physiol. , 293(2), H1038-45, 2007
  5. Coelho A, Dias A, Morais A, Nunes B, Ferreira E, Picanço I, Faustino P, Lavinha J, Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study., Eur. J. Haematol. , 92(3), 237-43, 2014
  6. Kalai M, Dridi M, Chaouch L, Moumni I, Ouragini H, Darragi I, Boudrigua I, Chaouachi D, Mellouli F, Bejaoui M, Abbes S, The role of rs1984112_G at CD36 gene in increasing reticulocyte level among sickle cell disease patients., Hematology , 2016
Created on 2017-01-23 11:25:01, Last reviewed on 2017-05-02 09:51:32 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.