GeneID: 191


Common Name: NOM1 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: N/A
HUGO Symbol: NOM1 Full Name: nucleolar protein with MIF4G domain 1
Exons: 11 Introns: 10

The NOM1 gene encodes a protein that contains MIF4G and/or MA3 domains. Proteins with these domains function in translation, cell growth, proliferation, transformation and apoptosis. NOM1 (nucleolar protein with MIF4G domain 1) interacts with members of the EIF4A family of ATP-dependent DEAD box RNA helicases that function in translation and nonsense-mediated decay. NOM1 interacts with protein phosphatase 1 (PP1), a serine/threonine kinase required for diverse cellular processes, including cell division, signalling and metabolism. The NOM1 RVXF motif is required for binding to PP1, while the amino terminus of NOM1 is necessary for its nucleolar localization. A polymorphism in this gene associated with HbF response to hydroxyurea in patients with sickle cell disease, while the cellular mechanism involved is currently unknown.

Synonyms: SGD1 , C7orf3 , PPP1R113


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Publications / Origin

  1. Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF, Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia., Gene , 347(1), 137-45, 2005 PubMed
  2. Gunawardena SR, Ruis BL, Meyer JA, Kapoor M, Conklin KF, NOM1 targets protein phosphatase I to the nucleolus., J. Biol. Chem. , 283(1), 398-404, 2008 PubMed
  3. Alexandrov A, Colognori D, Steitz JA, Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex., Genes Dev. , 25(10), 1078-90, 2011 PubMed
  4. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
Created on 2016-10-19 11:03:41, Last reviewed on (Show full history)

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