GeneID: 174


Common Name: F5 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_011806.1 (F5)
HUGO Symbol: F5 Full Name: Coagulation factor V
Exons: 25 Introns: 24

The F5 gene encodes coagulation factor V, an essential cofactor of the blood coagulation cascade. This factor circulates in an inactive form, and is cleaved by α-thrombin to produce the activated form, factor Va. Interaction of factor Va with factor Xa forms a prothrombinase complex on anionic phospholipid membranes, which catalyzes the conversion of prothrombin to α-thrombin. α-thrombin, in turn, converts fibrinogen into long strands of insoluble fibrin, which facilitates clotting of blood at the site of vascular injury. The α-thrombin required for factor V activation during the early phase of the coagulation process is derived from factor Xa cleavage of phospholipid-bound prothrombin via the prethrombin 2 pathway. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.

Synonyms: FVL , PCCF , THPH2 , RPRGL1


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Kane WH, Mruk JS, Majerus PW, Activation of coagulation factor V by a platelet protease., J. Clin. Invest. , 70(5), 1092-100, 1982 PubMed
  2. Kalafatis M, Egan JO, van 't Veer C, Cawthern KM, Mann KG, The regulation of clotting factors., Crit. Rev. Eukaryot. Gene Expr. , 7(3), 241-80, 1997 PubMed
  3. Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG, The factor V activation paradox., J. Biol. Chem. , 279(19), 19580-91, 2004 PubMed
Created on 2016-09-29 18:05:52, Last reviewed on (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Please publish modules in offcanvas position.