GeneID: 174



Names

Common Name: F5 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_011806.1 (F5)
HUGO Symbol: F5 Full Name: Coagulation factor V
Exons: 25 Introns: 24

Description:
The F5 gene encodes coagulation factor V, an essential cofactor of the blood coagulation cascade. This factor circulates in an inactive form, and is cleaved by α-thrombin to produce the activated form, factor Va. Interaction of factor Va with factor Xa forms a prothrombinase complex on anionic phospholipid membranes, which catalyzes the conversion of prothrombin to α-thrombin. α-thrombin, in turn, converts fibrinogen into long strands of insoluble fibrin, which facilitates clotting of blood at the site of vascular injury. The α-thrombin required for factor V activation during the early phase of the coagulation process is derived from factor Xa cleavage of phospholipid-bound prothrombin via the prethrombin 2 pathway. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.

Synonyms: FVL , PCCF , THPH2 , RPRGL1

Comments:
N/A

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Publications / Origin

  1. Kane WH, Mruk JS, Majerus PW, Activation of coagulation factor V by a platelet protease., J. Clin. Invest. , 70(5), 1092-100, 1982 PubMed
  2. Kalafatis M, Egan JO, van 't Veer C, Cawthern KM, Mann KG, The regulation of clotting factors., Crit. Rev. Eukaryot. Gene Expr. , 7(3), 241-80, 1997 PubMed
  3. Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG, The factor V activation paradox., J. Biol. Chem. , 279(19), 19580-91, 2004 PubMed
Created on 2016-09-29 18:05:52, Last reviewed on (Show full history)


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