GeneID: 168


Common Name: GSTP1 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_012075.1 (GSTP1)
HUGO Symbol: GSTP1 Full Name: glutathione S-transferase pi 1
Exons: 7 Introns: 6

GSTP1 is a member of the glutathione S-transferase (GST) family of detoxification enzymes, which catalyse conjugation reactions between the reduced form of glutathione (a nucleophile) and a variety of electrophilic compounds such as environmental toxins and carcinogens. GSTs are encoded by polymorphic genes divided into five classes: α, ζ, μ, π, and θ. GSTP1 belongs to the π (pi) class of the GST enzyme family and is the most prevalent isoform in non-hepatic tissues. It has been suggested a role in jun kinase inhibition. Polymoprhisms in this gene associated with risk of osteoporosis in β-thalassaemia major patients.

Synonyms: PI , DFN7 , GST3 , GSTP , FAEES3 , HEL-S-22


Publications / Origin

  1. Strange RC, Spiteri MA, Ramachandran S, Fryer AA, Glutathione-S-transferase family of enzymes., Mutat. Res. , 482(1), 21-6, 2001
  2. Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K, Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity., J. Neurochem. , 118(5), 902-14, 2011
  3. Ragab SM, Badr EA, Ibrahim AS, Evaluation of Glutathione-S-Transferase P1 Polymorphism and its Relation to Bone Mineral Density in Egyptian Children and Adolescents with Beta-Thalassemia Major., Mediterr J Hematol Infect Dis , 8(1), e2016004, 2016
Created on 2016-07-21 09:44:18, Last reviewed on (Show full history)

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